For many targets of pharmaceutical importance conformational changes of the receptor protein are relevant during the ligand binding process.A new docking approach, ReFlexIn (Receptor Flexibility by Interpolation), that combines receptor flexibility with the computationally efficient potential grid representation Stemware of receptor molecules has b
Applying Finite-Element and Boundary-Element Methods to Select Rational Design Version of Weld-Fabricated Bogie Frame Brackets of Locomotives and Railway Cars
There is proposed method to select rational design version of weld-fabricated bogie frame brackets of locomotives and railway cars.The selection is performed in accord with the outcomes of double-phase computation-based Pillows stress analysis in the welded joints.At the first stage general stressed state of a bogie frame as a whole is examined by
The Tomato Genome Encodes SPCH, MUTE, and FAMA Candidates That Can Replace the Endogenous Functions of Their Arabidopsis Orthologs
Stomatal abundance determines the maximum potential for gas exchange between the plant and the atmosphere.In Arabidopsis, it is set during organ development through complex genetic networks linking epidermal differentiation programs with environmental response circuits.Three related bHLH transcription factors, SPCH, MUTE, and FAMA, act as positive
Left atrial dissection after a supra-annular mitral valve replacement for endocarditis
Abstract Background High Chair Accessory Left atrial dissection is a rare and a potentially fatal complication of cardiac surgery.Multi-modal imagery is helpful for the diagnosis and to guide the treatment.Case presentation We report the case of a 66-year-old female patient who underwent a combined mitral and aortic valve replacement for degenerati